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There is no set amount of time that someone should take the medication, but it has been known to start having added effects after taking for longer than 1 year.

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Nevertheless, these data do suggest that intermittent PPI therapy may suffice after endoscopic therapy for high-risk stigmata.

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PPIs such as pantoprazole work by blocking the production of acid made in the stomach.

Of these tests, endoscopy is the only reliable method to diagnose erosive esophagitis and determine its severity ().

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Antisecretory medications such as antacids, Gaviscon, and sucralfate are used to protect the injured mucosa from gastric acid, but little evidence is available to support their use.

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NOTICE: This health information was not created by the University of Michigan Health System (UMHS) and may not necessarily reflect specific UMHS practices.

To evaluate the effectiveness of pantoprazole sodium for injection as an initial treatment to suppress gastric acid secretion, two studies were conducted.

In contrast to the obsolete assessment of heartburn as a single outcome criterion, a recently validated symptom assessment scale (ReQuest) () reliably covers a broad range of GERD-related symptoms on a daily basis by its dimension-orientated structure.

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Figure and Figure show the daily changes in the mean symptom scores of heartburn and acid reflux in all patients with each PPI.

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Pantoprazole has been approved for long-term treatment in people with pathological hypersecretory diseases (conditions resulting in the production of too much stomach acid).

Case 3: A patient taking pantoprazole, prednisone, rituximab, cotrimoxazole, and tiotropium was admitted to the hospital with hemoptysis, epistaxis, headache, and syncope.

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Pantoprazole Sodium Delayed-Release Tablets are prepared as enteric-coated tablets so that absorption of pantoprazole begins only after the tablet leaves the stomach.

Pantoprazole sodium USP is supplied as a delayed-release tablet for oral administration, available in 2 strengths.

Patients will participate in two 48-hour treatment periods during which intragastric (stomach) and esophageal pH will be recorded at 8-second intervals using a probe inserted through the nose and down to the stomach.

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Table 1: Recommended Dosing Schedule for Pantoprazole Sodium Delayed-release Tablets For adult patients who have not healed after 8 weeks of treatment, an additional 8-week course of pantoprazole sodium delayed-release tablets may be considered.

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In a multicenter, open-label trial of 35 patients with pathological hypersecretory conditions, such as Zollinger-Ellison syndrome, with or without multiple endocrine neoplasia-type I, pantoprazole sodium successfully controlled gastric acid secretion.

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